Keeping an eye on pain expression in primary somatosensory cortex
نویسندگان
چکیده
منابع مشابه
Thalamocortical connections of the primary somatosensory cortex
Although each subdivision of primary somatosensory cortex (SI) receives dense input from the thalamus, but the exact location and type of information that the fibers convey have not been identified yet. In the present study, the exact source of thalamocortical fibers to areas 2 and 3b was investigated using tract-tracing techniques. Following injection of tracer into area 3b, labeled neurons ...
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BACKGROUND Compared with somatotopical organization (somatotopy) in the postcentral gyrus in the tactile system, somatotopy in the pain system is not well understood. The aim of this study is to elucidate whether there is somatotopy in the human pain system. METHODS To elucidate the somatotopy of nociceptive neurons in the postcentral gyrus, the authors recorded pain-evoked cortical responses...
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Successful behavior requires selection and preferred processing of relevant sensory information. The cortical representation of relevant sensory information has been related to neuronal oscillations in the gamma frequency band. Pain is of invariably high behavioral relevance and, thus, nociceptive stimuli receive preferred processing. Here, by using magnetoencephalography, we show that selectiv...
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The intensity and submodality of pain are widely attributed to stimulus encoding by peripheral and subcortical spinal/trigeminal portions of the somatosensory nervous system. Consistent with this interpretation are studies of surgically anesthetized animals, demonstrating that relationships between nociceptive stimulation and activation of neurons are similar at subcortical levels of somatosens...
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Central pain syndrome (CPS) is a debilitating and chronic pain condition that results from a lesion or dysfunction in the CNS. The pathophysiological mechanisms underlying CPS are poorly understood. We recently demonstrated that CPS is associated with suppressed inputs from the inhibitory nucleus zona incerta to the posterior thalamus (PO). As a consequence, activity in PO is abnormally increas...
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ژورنال
عنوان ژورنال: NeuroImage
سال: 2020
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2020.116885